HSP27 inhibitor J2

Modify Date: 2024-01-09 13:39:33

HSP27 inhibitor J2 Structure
HSP27 inhibitor J2 structure
Common Name HSP27 inhibitor J2
CAS Number 2133499-85-9 Molecular Weight 264.30
Density N/A Boiling Point N/A
Molecular Formula C13H12O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HSP27 inhibitor J2


HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].

 Names

Name HSP27 inhibitor J2

 HSP27 inhibitor J2 Biological Activity

Description HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].
Related Catalog
Target

HSP27[2]

References

[1]. Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900.

[2]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.

 Chemical & Physical Properties

Molecular Formula C13H12O4S
Molecular Weight 264.30
Storage condition -20°C
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