2133499-85-9

2133499-85-9 structure

Name: HSP27 inhibitor J2
Chemical Name: HSP27 inhibitor J2
CAS Number: 2133499-85-9
Molecular Formula: C₁₃H₁₂O₄S
Molecular Weight: 264.30
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2019-10-08 07:30:52
Modify Date: 2024-01-09 13:39:33
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].

Name	HSP27 inhibitor J2

Description	HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP27[2]
References	[1]. Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900. [2]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.