HSP27 inhibitor J2

Names

[ Name ]:
HSP27 inhibitor J2

Biological Activity

[Description]:

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP27[2]

[References]

[1]. Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900.

[2]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₂O₄S

[ Molecular Weight ]:
264.30

[ Storage condition ]:
-20°C

Related Compounds

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