1-(3-chlorophenyl)biguanide hydrochloride

Modify Date: 2024-01-10 07:37:37

1-(3-chlorophenyl)biguanide hydrochloride structure	Common Name	1-(3-chlorophenyl)biguanide hydrochloride
	CAS Number	2113-05-5	Molecular Weight	248.11
	Density	1.49g/cm3	Boiling Point	434.1ºC at 760mmHg
	Molecular Formula	C₈H₁₁Cl₂N₅	Melting Point	190-194 °C(lit.)
	MSDS	Chinese USA	Flash Point	216.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of 1-(3-chlorophenyl)biguanide hydrochloride

m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1].

Name	2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine,hydrochloride
Synonym	More Synonyms

Description	m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vivo	m-CPBG hydrochloride (80 and 160 nM) 显著减少急性盐负荷引起的水摄入量[1]。 m-CPBG hydrochloride (third ventricle injection; 160 nM) 显著抑制低血容量动物的水摄入[1]。 m-CPBG hydrochloride (third ventricle injection; 320 nM) 减少缺水大鼠的水摄入量[1]。 m-CPBG hydrochloride (central administration）抑制中枢胆碱能和血管紧张素能通路药理学激活诱导的水摄入[1]。 Animal Model: Wistar male rats[1] Dosage: 80, 160 and 320 nM Administration: Ventricle injection Result: Decreased water intake induced by water deprivation, acute salt load and hypovolemia.
References	[1]. Castro L, et al. Central 5-HT(3) receptors and water intake in rats. Physiol Behav. 2002;77(2-3):349-359.

Density	1.49g/cm3
Boiling Point	434.1ºC at 760mmHg
Melting Point	190-194 °C(lit.)
Molecular Formula	C₈H₁₁Cl₂N₅
Molecular Weight	248.11
Flash Point	216.3ºC
Exact Mass	247.03900
PSA	97.78000
LogP	3.33540
Appearance of Characters	solid \| white
Vapour Pressure	9.74E-08mmHg at 25°C
Storage condition	Desiccate at RT
Water Solubility	H2O: soluble

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1780000

CHEMICAL NAME :: Biguanide, 1-(m-chlorophenyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 2113-05-5

LAST UPDATED :: 199007

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H10-Cl-N5.Cl-H

MOLECULAR WEIGHT :: 248.14

WISWESSER LINE NOTATION :: MUYZMYUM&MR CG &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 186 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,521,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Endocrine - hyperglycemia

REFERENCE :: IJOCAP Indian Journal of Chemistry. (New Delhi, India) V.1-13, 1963-75. Divided into Indian Journal of Chemistry, Section A and Indian Journal of Chemistry, Section B. Volume(issue)/page/year: 1,218,1962

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DU1780000

N/A

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1-(3-Chlorophenyl)biguanide hydrochloride

m-Chlorophenylbiguanide hydrochloride

MFCD00053019

N-m-Chlorophenylbiguanide hydrochloride

m-CPBG hydrochloride

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Product Name: 1-(3-chlorophenyl)biguanide hydrochloride
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Dayang Chem (Hangzhou) Co., Ltd.
China
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