1-(3-chlorophenyl)biguanide hydrochloride

Names

[ Name ]:
1-(3-chlorophenyl)biguanide hydrochloride

[Synonym ]:
1-(3-Chlorophenyl)biguanide hydrochloride
m-Chlorophenylbiguanide hydrochloride
MFCD00053019
N-m-Chlorophenylbiguanide hydrochloride
m-CPBG hydrochloride

Biological Activity

[Description]:

m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[In Vivo]

m-CPBG hydrochloride (80 and 160 nM) 显著减少急性盐负荷引起的水摄入量[1]。 m-CPBG hydrochloride (third ventricle injection; 160 nM) 显著抑制低血容量动物的水摄入[1]。 m-CPBG hydrochloride (third ventricle injection; 320 nM) 减少缺水大鼠的水摄入量[1]。 m-CPBG hydrochloride (central administration）抑制中枢胆碱能和血管紧张素能通路药理学激活诱导的水摄入[1]。 Animal Model: Wistar male rats[1] Dosage: 80, 160 and 320 nM Administration: Ventricle injection Result: Decreased water intake induced by water deprivation, acute salt load and hypovolemia.

[References]

[1]. Castro L, et al. Central 5-HT(3) receptors and water intake in rats. Physiol Behav. 2002;77(2-3):349-359.

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Boiling Point ]:
434.1ºC at 760mmHg

[ Melting Point ]:
190-194 °C(lit.)

[ Molecular Formula ]:
C₈H₁₁Cl₂N₅

[ Molecular Weight ]:
248.11

[ Flash Point ]:
216.3ºC

[ Exact Mass ]:
247.03900

[ PSA ]:
97.78000

[ LogP ]:
3.33540

[ Appearance of Characters ]:
solid | white

[ Vapour Pressure ]:
9.74E-08mmHg at 25°C

[ Storage condition ]:
Desiccate at RT

[ Water Solubility ]:
H2O: soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1780000

CHEMICAL NAME :: Biguanide, 1-(m-chlorophenyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 2113-05-5

LAST UPDATED :: 199007

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H10-Cl-N5.Cl-H

MOLECULAR WEIGHT :: 248.14

WISWESSER LINE NOTATION :: MUYZMYUM&MR CG &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 186 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,521,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Endocrine - hyperglycemia

REFERENCE :: IJOCAP Indian Journal of Chemistry. (New Delhi, India) V.1-13, 1963-75. Divided into Indian Journal of Chemistry, Section A and Indian Journal of Chemistry, Section B. Volume(issue)/page/year: 1,218,1962

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DU1780000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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