W-84 dibromide
W-84 dibromide structure
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Common Name | W-84 dibromide | ||
|---|---|---|---|---|
| CAS Number | 21093-51-6 | Molecular Weight | 708.52400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H44Br2N4O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of W-84 dibromideW-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine[1][2][3]. |
| Name | 3-(1,3-dioxoisoindol-2-yl)propyl-[6-[3-(1,3-dioxoisoindol-2-yl)propyl-dimethylazaniumyl]hexyl]-dimethylazanium,dibromide |
|---|---|
| Synonym | More Synonyms |
| Description | W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine[1][2][3]. |
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| Related Catalog | |
| Target |
muscarinic acetylcholine receptors[1] |
| In Vitro | The stabilizing effect of W-84 (dibromide) on antagonist-receptor complexes may explain the overadditive protective action exerted by the combination of atropine and W-84 (dibromide) against organophosphate intoxication[1]. W-84 (dibromide) not only inhibits radioligand association but also strongly stabilizes antagonist-receptor complexes[2]. |
| References |
| Molecular Formula | C32H44Br2N4O4 |
|---|---|
| Molecular Weight | 708.52400 |
| Exact Mass | 706.17300 |
| PSA | 74.76000 |
| InChIKey | DZRJZDQAGMZGGA-UHFFFAOYSA-L |
| SMILES | C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O.[Br-].[Br-] |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
|
~96%
W-84 dibromide CAS#:21093-51-6 |
| Literature: Heller, Eberhard; Lautenschlaeger, Werner; Holzgrabe, Ulrike Tetrahedron Letters, 2009 , vol. 50, # 12 p. 1321 - 1323 |
|
~%
W-84 dibromide CAS#:21093-51-6 |
| Literature: Schmitz, Jens; Heller, Eberhard; Holzgrabe, Ulrike Monatshefte fur Chemie, 2007 , vol. 138, # 2 p. 171 - 174 |
|
~%
W-84 dibromide CAS#:21093-51-6 |
| Literature: Schmitz, Jens; Heller, Eberhard; Holzgrabe, Ulrike Monatshefte fur Chemie, 2007 , vol. 138, # 2 p. 171 - 174 |
![2-[3-(dimethylamino)propyl]isoindole-1,3-dione structure](https://image.chemsrc.com/caspic/242/13474-65-2.png)
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Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria.
Eur. J. Pharmacol. 272 , 103-106, (1995) Alcuronium is known to stabilize allosterically the binding of the muscarinic antagonist N-methylscopolamine to muscarinic M2 receptors and thus to elevate the equilibrium binding of N-methylscopolami... |
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Allosteric modulation of G protein-coupled receptors: perspectives and recent developments.
Drug Discov. Today 9 , 752-758, (2004) Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or... |
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A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts.
J. Pharm. Pharmacol. 46(2) , 108-12, (1994) W84 (N,N,N',N'-tetramethyl-N,N'-bis-(3-phthalimidopropyl)-N,N'-hexane- 1,6- diyl-bis-ammonium dibromide) is a potent stabilizer of antagonist binding to muscarinic receptors; however, W84 hydrolyses i... |
| Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide |
| Hdmppa |
| W-84 dibromide |
| W-84 |