w-Conotoxin SVIB

Modify Date: 2024-01-08 18:01:45

w-Conotoxin SVIB Structure
w-Conotoxin SVIB structure
Common Name w-Conotoxin SVIB
CAS Number 150433-82-2 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C105H176N38O36S6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of w-Conotoxin SVIB


w-Conotoxin SVIB is a peptide toxin, it can be isolated from Conus venoms. w-Conotoxin SVIB inhibits twitch response with an IC50 value of 37 nM. w-Conotoxin SVIB induces respiratory distress and it can be lethal to mice at a high concentration[1][2].

 Names

Name OMEGA-CONOTOXIN SVIB

 w-Conotoxin SVIB Biological Activity

Description w-Conotoxin SVIB is a peptide toxin, it can be isolated from Conus venoms. w-Conotoxin SVIB inhibits twitch response with an IC50 value of 37 nM. w-Conotoxin SVIB induces respiratory distress and it can be lethal to mice at a high concentration[1][2].
Related Catalog
Target

IC50: 37 nM (twitch response at 0.1 Hz)[2]

In Vitro w-Conotoxin SVIB (0.1-1000 nM; 20 min) inhibits twitch response at 0.1 Hz with an IC50 value of 37 nM[2].
In Vivo w-Conotoxin SVIB (20 pmol/g; s.c. once) causes paralysis and death in fish[1]. w-Conotoxin SVIB causes mouse respiratory distress at around 70 pmol/g and it is lethal to mouse at around 300 pmol/g[1].
References

[1]. Ramilo CA, et al. Novel alpha- and omega-conotoxins from Conus striatus venom. Biochemistry. 1992 Oct 20;31(41):9919-26.

[2]. Hong SJ, et al. Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by omega-conotoxins GVIA, MVIIA, MVIIC and SVIB. Br J Pharmacol. 1996 Jun;118(3):797-803.

 Chemical & Physical Properties

Molecular Formula C105H176N38O36S6
Storage condition −20°C

 Safety Information

WGK Germany 3