942289-87-4
942289-87-4 structure
- Name: PI 828
- Chemical Name: 8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one
- CAS Number: 942289-87-4
- Molecular Formula: C19H18N2O3
- Molecular Weight: 322.35800
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2016-07-11 05:22:07
- Modify Date: 2024-01-02 23:52:20
-
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1].
| Name | 8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one |
|---|---|
| Synonyms |
HMS3229H13
W-84 dibromide HMS3266C12 |
| Description | PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
p110α:173 nM (IC50) CK2:149 nM (IC50) CK2α2:1.127 μM (IC50) |
| In Vitro | PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells[2]. PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis[3]. Cell Viability Assay[2] Cell Line: 4T1 breast cancer cells and 4306 ovarian cancer cells Concentration: 0.01, 0.1, 1, 10 and 100 μM Incubation Time: Result: Exhibited cytotoxic effect. Apoptosis Analysis[3] Cell Line: Human embryonic carcinoma NCCIT cells Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM Incubation Time: 48 hours Result: Concentrations of ranging from 0.78 to 3.12 µM decreased caspase 3 activation; higher concentrations caused apoptosis. |
| References |
| Density | 1.316g/cm3 |
|---|---|
| Boiling Point | 534.2ºC at 760 mmHg |
| Molecular Formula | C19H18N2O3 |
| Molecular Weight | 322.35800 |
| Flash Point | 276.9ºC |
| Exact Mass | 322.13200 |
| PSA | 68.70000 |
| LogP | 3.52500 |
| Index of Refraction | 1.658 |