HA-100 hydrochloride

Modify Date: 2025-08-21 09:32:42

HA-100 hydrochloride structure	Common Name	HA-100 hydrochloride
	CAS Number	210297-47-5	Molecular Weight	350.26
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₇Cl₂N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HA-100 hydrochloride

HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor[1][2].

Name	5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
Synonym	More Synonyms

Description	HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Myosin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	PKA:8 μM (IC50) PKC:12 μM (IC50) PKC:6.5 μM (Ki) PKG:4 μM (IC50) MLCK:240 μM (IC50) MLCK:61 μM (Ki)
References	[1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. [2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

Molecular Formula	C₁₃H₁₇Cl₂N₃O₂S
Molecular Weight	350.26
Exact Mass	349.041840
PSA	70.68000
LogP	3.78020
InChIKey	ZKQAPKKKTQCVKG-UHFFFAOYSA-N
SMILES	Cl.Cl.O=S(=O)(c1cccc2cnccc12)N1CCNCC1

Isoquinoline, 5-(1-piperazinylsulfonyl)-, hydrochloride (1:2)

5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride

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HA-100 hydrochloride

Use of HA-100 hydrochloride

Names

HA-100 hydrochloride Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.