Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HA-100
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: HA-100
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(5-isoquinolinesulfonyl)piperazine, dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

84468-24-6

84468-24-6 structure

84468-24-6 structure

Name: HA-100
Chemical Name: 5-piperazin-1-ylsulfonylisoquinoline
CAS Number: 84468-24-6
Molecular Formula: C₁₃H₁₅N₃O₂S
Molecular Weight: 277.34200
Catalog: Signaling Pathways Cytoskeleton Myosin
Create Date: 2018-12-03 16:21:38
Modify Date: 2025-08-29 18:05:50
HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), Protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively.

Name	5-piperazin-1-ylsulfonylisoquinoline
Synonyms	Tocris-0543 ha-100 MFCD01310980

Description	HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), Protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Myosin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Cancer
Target	PKC:12 μM (IC50) PKG:4 μM (IC50) PKA:8 μM (IC50) MLCK:240 μM (IC50)
References	[1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

Density	1.332g/cm3
Boiling Point	497.4ºC at 760 mmHg
Molecular Formula	C₁₃H₁₅N₃O₂S
Molecular Weight	277.34200
Flash Point	254.6ºC
Exact Mass	277.08800
PSA	70.68000
LogP	2.17620
Index of Refraction	1.639
Storage condition	−20°C

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
RTECS	TM0862600
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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