HA-100

Modify Date: 2024-01-11 14:03:08

HA-100 Structure
HA-100 structure
Common Name HA-100
CAS Number 84468-24-6 Molecular Weight 277.34200
Density 1.332g/cm3 Boiling Point 497.4ºC at 760 mmHg
Molecular Formula C13H15N3O2S Melting Point N/A
MSDS N/A Flash Point 254.6ºC

 Use of HA-100


HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), Protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively.

 Names

Name 5-piperazin-1-ylsulfonylisoquinoline
Synonym More Synonyms

 HA-100 Biological Activity

Description HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), Protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively.
Related Catalog
Target

PKC:12 μM (IC50)

PKG:4 μM (IC50)

PKA:8 μM (IC50)

MLCK:240 μM (IC50)

References

[1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

 Chemical & Physical Properties

Density 1.332g/cm3
Boiling Point 497.4ºC at 760 mmHg
Molecular Formula C13H15N3O2S
Molecular Weight 277.34200
Flash Point 254.6ºC
Exact Mass 277.08800
PSA 70.68000
LogP 2.17620
Index of Refraction 1.639
Storage condition −20°C

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
WGK Germany 3
RTECS TM0862600
HS Code 2935009090

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

Tocris-0543
ha-100
MFCD01310980
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Price: $79/10mM*1mLinDMSO

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