HA-100 hydrochloride

Names

[ Name ]:
HA-100 hydrochloride

[Synonym ]:
Isoquinoline, 5-(1-piperazinylsulfonyl)-, hydrochloride (1:2)
5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride

Biological Activity

[Description]:

HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> Myosin

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK

Signaling Pathways >> TGF-beta/Smad >> PKC

Signaling Pathways >> Stem Cell/Wnt >> ROCK

Signaling Pathways >> TGF-beta/Smad >> ROCK

[Target]

PKA:8 μM (IC50)

PKC:12 μM (IC50)

PKC:6.5 μM (Ki)

PKG:4 μM (IC50)

MLCK:240 μM (IC50)

MLCK:61 μM (Ki)

[References]

[1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

[2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₇Cl₂N₃O₂S

[ Molecular Weight ]:
350.26

[ Exact Mass ]:
349.041840

[ PSA ]:
70.68000

[ LogP ]:
3.78020

Related Compounds

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