MAP4K4-IN-37

Modify Date: 2024-04-02 11:38:37

MAP4K4-IN-37 Structure
MAP4K4-IN-37 structure
 Common Name MAP4K4-IN-37
CAS Number 2089334-01-8 Molecular Weight 382.844
Density N/A Boiling Point N/A
Molecular Formula C21H19ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MAP4K4-IN-37


MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice

 Names

Name MAP4K4-IN-37

 MAP4K4-IN-37 Biological Activity

Description MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice
References References 1. Dow RL, et al. J Med Chem. 2018 Apr 12;61(7):3114-3125. View Related Products by Target MAP4K

 Chemical & Physical Properties

Molecular Formula C21H19ClN2O3
Molecular Weight 382.844
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Chemsrc provides MAP4K4-IN-37(CAS#:2089334-01-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of MAP4K4-IN-37 are included as well.>> amp version: MAP4K4-IN-37

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