1823133-56-7
1823133-56-7 structure
- Name: Dynein2-IN-37
- Chemical Name: Dynein2-IN-37
- CAS Number: 1823133-56-7
- Molecular Formula: C25H17Cl2N3O3
- Molecular Weight: 478.329
- Create Date: 2020-01-12 16:32:32
- Modify Date: 2023-01-15 15:14:14
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Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM); directly targets the heavy chains of both dynein isoforms and explore the structure-activity landscape of these inhibitors in vitro and in cells; inhibits retrograde ciliary GLI2 transport more strongly than ciliobrevin A, effectively disrupts Hedgehog signaling, intraflagellar transport, and ciliogenesis.
| Name | Dynein2-IN-37 |
|---|
| Description | Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM); directly targets the heavy chains of both dynein isoforms and explore the structure-activity landscape of these inhibitors in vitro and in cells; inhibits retrograde ciliary GLI2 transport more strongly than ciliobrevin A, effectively disrupts Hedgehog signaling, intraflagellar transport, and ciliogenesis. |
|---|---|
| References | References 1. See SK, et al. ACS Chem Biol. 2016 Jan 15;11(1):53-60. View Related Products by Target Dynein |
| Molecular Formula | C25H17Cl2N3O3 |
|---|---|
| Molecular Weight | 478.329 |