1783856-40-5
1783856-40-5 structure
- Name: β-catenin-IN-37
- Chemical Name: β-catenin-IN-37
- CAS Number: 1783856-40-5
- Molecular Formula: C13H9N9O
- Molecular Weight: 307.277
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 20:27:50
- Modify Date: 2024-01-20 19:03:30
-
β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively.
| Name | β-catenin-IN-37 |
|---|
| Description | β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively. |
|---|---|
| References | References 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. View Related Products by Target Beta-catenin |
| Molecular Formula | C13H9N9O |
|---|---|
| Molecular Weight | 307.277 |