2011784-92-0
2011784-92-0 structure
- Name: Tubulin polymerization-IN-37
- Chemical Name: Tubulin polymerization-IN-37
- CAS Number: 2011784-92-0
- Molecular Formula: C19H20N2O4
- Molecular Weight: 340.37
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2022-10-23 17:58:10
- Modify Date: 2024-04-02 17:07:47
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Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1].
| Name | Tubulin polymerization-IN-37 |
|---|
| Description | Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1]. |
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| Related Catalog | |
| Target |
Tubulin polymerization[1] |
| In Vitro | Tubulin polymerization-IN-37 (compound 2f, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%[1]. Tubulin polymerization-IN-37 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells[1]. Tubulin polymerization-IN-37 (5 μΜ) inhibits colchicine binding to tubulin by 80%[1]. Tubulin polymerization-IN-37 shows cytotoxicity against MCF-7 cells (IC50: 0.21 μΜ)[1]. Cell Proliferation Assay[1] Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells. Concentration: 0-10 μΜ Incubation Time: 72 h Result: Inhibited cell proliferation to 28.1%, 8.6%, 7.3%, 13.8% at 1 μΜ, respectively.IC50s: 0.12, 0.07, 0.08, 0.07 μΜ, respectively. Cell Cycle Analysis[1] Cell Line: VL51 and MINO cells Concentration: 50 and 500 nM Incubation Time: 24, 48 and 72 h Result: Arrested cell in G2/M phase. |
| References |
| Molecular Formula | C19H20N2O4 |
|---|---|
| Molecular Weight | 340.37 |