2089334-01-8
2089334-01-8 structure
- Name: MAP4K4-IN-37
- Chemical Name: MAP4K4-IN-37
- CAS Number: 2089334-01-8
- Molecular Formula: C21H19ClN2O3
- Molecular Weight: 382.844
- Create Date: 2020-01-20 14:59:56
- Modify Date: 2024-04-02 11:38:37
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MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice
| Name | MAP4K4-IN-37 |
|---|
| Description | MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice |
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| References | References 1. Dow RL, et al. J Med Chem. 2018 Apr 12;61(7):3114-3125. View Related Products by Target MAP4K |
| Molecular Formula | C21H19ClN2O3 |
|---|---|
| Molecular Weight | 382.844 |