PF-06795071

Modify Date: 2025-11-28 18:00:54

PF-06795071 Structure
PF-06795071 structure
Common Name PF-06795071
CAS Number 2075629-81-9 Molecular Weight 399.34
Density N/A Boiling Point N/A
Molecular Formula C18H17F4N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PF-06795071


PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM[1].

 Names

Name PF-06795071

 PF-06795071 Biological Activity

Description PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM[1].
Related Catalog
Target

IC50: 3 nM (MAGL)[1]

In Vitro PF-06795071 shows excellent selectivity against FAAH with an IC50 of 3.1 μM[1].
References

[1]. McAllister LA, et al. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. J Med Chem. 2018 Apr 12;61(7):3008-3026.

 Chemical & Physical Properties

Molecular Formula C18H17F4N3O3
Molecular Weight 399.34
InChIKey MEDCQBUTCWNKGW-XFDYKOMQSA-N
SMILES O=C(OC(CO)C(F)(F)F)N1CC2C(C1)C2c1ccn(-c2ccc(F)cc2)n1
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