PF-05085727

Modify Date: 2025-08-29 11:49:48

PF-05085727 Structure
PF-05085727 structure
Common Name PF-05085727
CAS Number 1415637-72-7 Molecular Weight 413.40
Density N/A Boiling Point N/A
Molecular Formula C20H18F3N7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PF-05085727


PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM.

 Names

Name PF-05085727

 PF-05085727 Biological Activity

Description PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM.
Related Catalog
Target

PDE2A:2 nM (IC50)

References

[1]. Helal CJ, et al. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J Med Chem. 2017 Jul 13;60(13):5673-5698.

 Chemical & Physical Properties

Molecular Formula C20H18F3N7
Molecular Weight 413.40
InChIKey SHAVEYUXRBIMLA-UHFFFAOYSA-N
SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(C(F)(F)F)cc1
Storage condition 2-8℃
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