1863905-38-7
1863905-38-7 structure
- Name: PF-06737007
- Chemical Name: PF-06737007
- CAS Number: 1863905-38-7
- Molecular Formula: C25H28F4N2O6
- Molecular Weight: 528.49
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Trk Receptor
- Create Date: 2019-03-03 16:28:06
- Modify Date: 2023-01-27 11:25:53
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PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
| Name | PF-06737007 |
|---|
| Description | PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. |
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| Related Catalog | |
| Target |
TrkA:7.7 nM (IC50, in cell-based assays) TrkB:15 nM (IC50, in cell-based assays) TrkC:3.9 nM (IC50, in cell-based assays) |
| In Vitro | PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM[1]. |
| References |
| Molecular Formula | C25H28F4N2O6 |
|---|---|
| Molecular Weight | 528.49 |
| Hazard Codes | Xi |
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