PF 945863

Modify Date: 2024-01-10 20:58:55

PF 945863 Structure
PF 945863 structure
Common Name PF 945863
CAS Number 893556-85-9 Molecular Weight 824.014
Density 1.3±0.1 g/cm3 Boiling Point 924.7±65.0 °C at 760 mmHg
Molecular Formula C44H65N5O10 Melting Point N/A
MSDS N/A Flash Point 513.0±34.3 °C

 Use of PF 945863


PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].

 Names

Name (3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
Synonym More Synonyms

 PF 945863 Biological Activity

Description PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].
Related Catalog
In Vitro PF-945863 is an orally active macrolide antibiotic[2].
References

[1]. Zientek M, et al. In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010;38(8):1322-1327.

[2]. Magee TV, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009;52(23):7446-7457.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 924.7±65.0 °C at 760 mmHg
Molecular Formula C44H65N5O10
Molecular Weight 824.014
Flash Point 513.0±34.3 °C
Exact Mass 823.473145
LogP 3.14
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.585

 Synonyms

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-( ;dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R)-
(3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3] ;oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
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