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PF 945863

Names

[ CAS No. ]:
893556-85-9

[ Name ]:
PF 945863

[Synonym ]:
2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-( ;dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R)-
(3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3] ;oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside

Biological Activity

[Description]:

PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

PF-945863 is an orally active macrolide antibiotic[2].

[References]

[1]. Zientek M, et al. In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010;38(8):1322-1327.

[2]. Magee TV, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009;52(23):7446-7457.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
924.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C44H65N5O10

[ Molecular Weight ]:
824.014

[ Flash Point ]:
513.0±34.3 °C

[ Exact Mass ]:
823.473145

[ LogP ]:
3.14

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.585

Related Compounds