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PF-05085727

Names

[ CAS No. ]:
1415637-72-7

[ Name ]:
PF-05085727

Biological Activity

[Description]:

PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Neurological Disease

[Target]

PDE2A:2 nM (IC50)


[References]

[1]. Helal CJ, et al. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J Med Chem. 2017 Jul 13;60(13):5673-5698.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18F3N7

[ Molecular Weight ]:
413.40

[ Storage condition ]:
2-8℃

Related Compounds