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PF-04531083

Names

[ CAS No. ]:
1079400-07-9

[ Name ]:
PF-04531083

[Synonym ]:
40497CY7Y3
MFCD28411617
PF-04531083
N-[6-Amino-5-(2-chloro-5-methoxyphenyl)-2-pyridinyl]-1-methyl-1H-pyrazole-5-carboxamide
1H-Pyrazole-5-carboxamide, N-[6-amino-5-(2-chloro-5-methoxyphenyl)-2-pyridinyl]-1-methyl-

Biological Activity

[Description]:

PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[Target]

NaV1.8[1]


[References]

[1]. Bagal SK, et al. Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.


[Related Small Molecules]

EIPA | Riluzole | Ginsenoside Rg3 | Cariporide | Eleclazine hydrochloride | GS967 | Tenapanor | Triamterene | Ranolazine dihydrochloride | PF 05089771 | flecainide acetate | A-803467 | CNV1014802 (hydrochloride) | Zonisamide | Cinchocaine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
471.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H16ClN5O2

[ Molecular Weight ]:
357.794

[ Flash Point ]:
238.7±28.7 °C

[ Exact Mass ]:
357.099243

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.670

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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