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PF 05089771

Names

[ CAS No. ]:
1235403-62-9

[ Name ]:
PF 05089771

[Synonym ]:
(1aR,12bS)-8-Cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide
PF 05089771

Biological Activity

[Description]:

PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Others

[References]

[1]. Norinder U, et al. QSAR investigation of NaV1.7 active compounds using the SVM/Signature approach and the Bioclipse Modeling platform. Bioorg Med Chem Lett. 2013 Jan 1;23(1):261-3.

[2]. BEAUDOIN, et al. SULFONAMIDE DERIVATIVES . Patent WO/2010/079443 A1.


[Related Small Molecules]

EIPA | Riluzole | Ginsenoside Rg3 | Cariporide | Eleclazine hydrochloride | GS967 | Tenapanor | Triamterene | Ranolazine dihydrochloride | flecainide acetate | A-803467 | CNV1014802 (hydrochloride) | Zonisamide | Cinchocaine | ICA 121431

Chemical & Physical Properties

[ Molecular Formula ]:
C18H12Cl2FN5O3S2

[ Molecular Weight ]:
500.35400

[ Exact Mass ]:
498.97400

[ PSA ]:
159.61000

[ LogP ]:
6.88940

[ Storage condition ]:
2-8℃

Related Compounds

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