PF-06795071

Names

[ CAS No. ]:
2075629-81-9

[ Name ]:
PF-06795071

Biological Activity

[Description]:

PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

IC50: 3 nM (MAGL)[1]

[In Vitro]

PF-06795071 shows excellent selectivity against FAAH with an IC50 of 3.1 μM[1].

[References]

[1]. McAllister LA, et al. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. J Med Chem. 2018 Apr 12;61(7):3008-3026.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇F₄N₃O₃

[ Molecular Weight ]:
399.34

Related Compounds

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