Deferasirox

Deferasirox Structure
Deferasirox
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Common Name Deferasirox
CAS Number 201530-41-8 Molecular Weight 373.362
Density 1.4±0.1 g/cm3 Boiling Point 672.1±65.0 °C at 760 mmHg
Molecular Formula C21H15N3O4 Melting Point 260-262ºC
MSDS N/A Flash Point 360.3±34.3 °C

 Use of Deferasirox


Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload.

 Names

Name deferasirox
Synonym More Synonyms

 Deferasirox Biological Activity

Description Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload.
Related Catalog
In Vitro In LX-2 cells treated with 50 μM deferasirox for 12 h, α1(I)procollagen expression is decreased by 25%, with maximal reductions (10-fold) seen following 24-120 h of treatment. Similarly, α-smooth muscle actin (αSMA) expression is significantly lower[1]. Deferasirox had anti-proliferative effects on HL-60 or KG-1 myeloid leukemia cell lines at a concentration as low as 5 μM . The cytotoxicity is both dose and time dependent[2]. The viability of both EL4 cells and L1210 cells incubated with deferasirox decrease in a concentration-dependent manner[3].
In Vivo The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy[3].
Solvent
In Vitro:

10 mM in DMSO

Solubility
1 mM 2.6784 mL 13.3919 mL 26.7838 mL
5 mM 0.5357 mL 2.6784 mL 5.3568 mL
10 mM 0.2678 mL 1.3392 mL 2.6784 mL
Cell Assay Deferasirox is dissolved in DMSO. HL-60 or KG-1 cells are treated with 0, 5, 10, 50 μM of deferasirox for 24 or 48 h, and proliferation is determined by an MTT assay[2].
Animal Admin Mice: Murine leukemia cells are injected subcutaneously into the right flank of mice. Deferasirox is dissolved in distilled water and orally administered at 20 mg/kg until the cumulative dose reaches 300 mg/kg. The mice are observed and weighed daily[3].
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(O)C1=CC=C(N2N=C(C3=CC=CC=C3O)N=C2C4=CC=CC=C4O)C=C1
References

[1]. Sobbe A, et al. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. J Gastroenterol Hepatol. 2015 Mar;30(3):638-45.

[2]. Kim JL, et al. The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targetingcaspase. Acta Haematol. 2011;126(4):241-5.

[3]. Lee DH, et al. Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Exp Hematol. 2013 Jun;41(6):539-46.

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Related Doc

SDS |COA |HNMR |LCMS

*The above documents are provided by Medchemexpress and are for scientific research only.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 672.1±65.0 °C at 760 mmHg
Melting Point 260-262ºC
Molecular Formula C21H15N3O4
Molecular Weight 373.362
Flash Point 360.3±34.3 °C
Exact Mass 373.106262
PSA 107.95000
LogP 6.43
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.699
Storage condition -20°C Freezer

 Safety Information

HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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  • MedChemExpress LLC
  • China
  • Product Name: Deferasirox
  • Price: ¥770.0/5mg ¥2900.0/25mg ¥1350.0/10mg ¥7900.0/100mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Miss Gao

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Price: $92/10mM*1mLinDMSO

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