n6-methyl-2'-deoxy-adenosine

Modify Date: 2024-01-14 22:34:26

n6-methyl-2'-deoxy-adenosine Structure
n6-methyl-2'-deoxy-adenosine structure
Common Name n6-methyl-2'-deoxy-adenosine
CAS Number 2002-35-9 Molecular Weight 265.27
Density 1.72g/cm3 Boiling Point 603.6ºC at 760mmHg
Molecular Formula C11H15N5O3 Melting Point N/A
MSDS USA Flash Point 318.8ºC

 Use of n6-methyl-2'-deoxy-adenosine


N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol
Synonym More Synonyms

 n6-methyl-2'-deoxy-adenosine Biological Activity

Description N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.72g/cm3
Boiling Point 603.6ºC at 760mmHg
Molecular Formula C11H15N5O3
Molecular Weight 265.27
Flash Point 318.8ºC
Exact Mass 265.11700
PSA 105.32000
Appearance of Characters Powder | White to Off-white
Vapour Pressure 2.03E-15mmHg at 25°C
Index of Refraction 1.78
Storage condition −20°C
Water Solubility Soluble in water

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29349990

 Synthetic Route

~78%

n6-methyl-2'-deoxy-adenosine Structure

n6-methyl-2'-de...

CAS#:2002-35-9

Literature: Helvetica Chimica Acta, , vol. 69, p. 1034 - 1040

~31%

n6-methyl-2'-deoxy-adenosine Structure

n6-methyl-2'-de...

CAS#:2002-35-9

Detail
Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2787 - 2792

~21%

n6-methyl-2'-deoxy-adenosine Structure

n6-methyl-2'-de...

CAS#:2002-35-9

Detail
Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1327 - 1330

~%

n6-methyl-2'-deoxy-adenosine Structure

n6-methyl-2'-de...

CAS#:2002-35-9

Literature: Collection of Czechoslovak Chemical Communications, , vol. 59, # 10 p. 2303 - 2330

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 Synonyms

N-6-methyl-2'-deoxyribofuranosil adenine
N6-Methyl-2'-desoxy-adenosin
N6-Methyldeoxyadenosine
2'-Deoxy-N6-methylado
Adenosine,2'-deoxy-N-methyl
N6-Methyl-2'-deoxyadenosine
2'-deoxy-N6-methyladenosine
N6-methyl-2'-deoxy-adenosine