n6-methyl-2'-deoxy-adenosine

Names

[ CAS No. ]:
2002-35-9

[ Name ]:
n6-methyl-2'-deoxy-adenosine

[Synonym ]:
N-6-methyl-2'-deoxyribofuranosil adenine
N6-Methyl-2'-desoxy-adenosin
N6-Methyldeoxyadenosine
2'-Deoxy-N6-methylado
Adenosine,2'-deoxy-N-methyl
N6-Methyl-2'-deoxyadenosine
2'-deoxy-N6-methyladenosine
N6-methyl-2'-deoxy-adenosine

Biological Activity

[Description]:

N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.72g/cm3

[ Boiling Point ]:
603.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₅N₅O₃

[ Molecular Weight ]:
265.27

[ Flash Point ]:
318.8ºC

[ Exact Mass ]:
265.11700

[ PSA ]:
105.32000

[ Appearance of Characters ]:
Powder | White to Off-white

[ Vapour Pressure ]:
2.03E-15mmHg at 25°C

[ Index of Refraction ]:
1.78

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in water

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.

Br. J. Pharmacol. 171(14) , 3404-19, (2014)

Despite the abundant expression of the UDP-sensitive P2Y6 receptor in urothelial cells and sub-urothelial myofibroblasts its role in the control of bladder function is not well understood.We compared ...

GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat.

Neurosci. Lett. 584 , 168-72, (2014)

We examined ATP-induced intracellular Ca(2+) ([Ca(2+)]i) responses in the neurons and satellite cells from one of the viscerosensory ganglia, the nodose ganglion (NG), as well as the GABA-mediated mod...

Pharmacological characterization of the human P2Y13 receptor.

Mol. Pharmacol. 64 , 104-112, (2003)

The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional properties: coupling to Gi and responsivene...

Related Compounds

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