Dopamine serotonin antagonist-1
Modify Date: 2025-08-22 10:45:53
Dopamine serotonin antagonist-1 structure
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Common Name | Dopamine serotonin antagonist-1 | ||
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| CAS Number | 1977-07-7 | Molecular Weight | 292.37800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H20N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Dopamine serotonin antagonist-1Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively. |
| Name | 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
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| Synonym | More Synonyms |
| Description | Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively. |
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| Related Catalog | |
| Target |
Ki: 200 nM (Dopamne D1), 2500 nM (Dopamne D2), 420 nM (Dopamne D4), 39 nM (Serotonin S2A), 84 nM (Serotonin S2C), 200 nM (Serotonin S3)[1] |
| Kinase Assay | To measure the affinity for the serotonin 5-3 (6-HTs) receptor, membranes from confluent NG108-15 cell monolayers are prepared and stored. The assay tubes, in triplicate, receive 100 μL of 1 nM [3H]GR65630, 50 μL of test compound (include Dopamine serotonin antagonist-1) or 10 pM metoclopramide for nonspecific binding, 200 μL membrane suspension (0.1 to 0.2 mglassay tube) in a final volume of 500 μL. Incubation proceeds at 37°C for 30 min and is terminated by filtration of the mixture through GF/B glass fiber filters, presoaked in 0.1% polyethylenimine, using a Brandel cell harvester. The filters are rinsed with two 5-mL portions of ice-cold HEPES-KOH, pH 7.4, buffer. The filters are transferred to scintillation vials to which 4 mL of Beckman Ready Protein is added, and the radioactivity is determined by liquid scintillation spectrometry[1]. |
| References |
| Molecular Formula | C18H20N4 |
|---|---|
| Molecular Weight | 292.37800 |
| Exact Mass | 292.16900 |
| PSA | 30.87000 |
| LogP | 2.51870 |
| Vapour Pressure | 1.48E-08mmHg at 25°C |
| InChIKey | VQHITFFJBFOMBG-UHFFFAOYSA-N |
| SMILES | CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1 |
| Storage condition | 2-8℃ |
| Dechloroclozapine |
| Dopamine serotonin antagonist-1 |