MT16-001
Modify Date: 2024-02-12 18:46:10
MT16-001 structure
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Common Name | MT16-001 | ||
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| CAS Number | 1895049-73-6 | Molecular Weight | 298.364 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H14N4Os | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MT16-001MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).MT16-001 inhibits structurally unrelated DUB USP30 with similar potency.MT16-001 showed cytotoxicity in human embryonic kidney cells (HEK293) with EC50 of 730 nM, effectively engaged UCHL1 in cells with EC50 of 550 nM.MT16-001 showed excellent selectivity for UCHL1 across the UCH family: UCHL1, UCHL3, UCHL5 and BAP1. |
| Name | MT16-001 |
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| Description | MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).MT16-001 inhibits structurally unrelated DUB USP30 with similar potency.MT16-001 showed cytotoxicity in human embryonic kidney cells (HEK293) with EC50 of 730 nM, effectively engaged UCHL1 in cells with EC50 of 550 nM.MT16-001 showed excellent selectivity for UCHL1 across the UCH family: UCHL1, UCHL3, UCHL5 and BAP1. |
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| References | 1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943. |
| Molecular Formula | C15H14N4Os |
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| Molecular Weight | 298.364 |