RP 001 hydrochloride

Modify Date: 2024-01-15 13:57:16

RP 001 hydrochloride structure	Common Name	RP 001 hydrochloride
	CAS Number	1781880-34-9	Molecular Weight	468.93
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₅ClN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RP 001 hydrochloride

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].

Name	RP-001 hydrochloride

Description	RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Neurological Disease
In Vitro	RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels[1].
In Vivo	RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].
References	[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6.

Molecular Formula	C₂₄H₂₅ClN₄O₄
Molecular Weight	468.93

RP 001 hydrochloride

Use of RP 001 hydrochloride

Names

RP 001 hydrochloride Biological Activity

Chemical & Physical Properties