MT16-001
Names
[ CAS No. ]:
1895049-73-6
[ Name ]:
MT16-001
Biological Activity
[Description]:
MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).MT16-001 inhibits structurally unrelated DUB USP30 with similar potency.MT16-001 showed cytotoxicity in human embryonic kidney cells (HEK293) with EC50 of 730 nM, effectively engaged UCHL1 in cells with EC50 of 550 nM.MT16-001 showed excellent selectivity for UCHL1 across the UCH family: UCHL1, UCHL3, UCHL5 and BAP1.
[References]
1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943.
Chemical & Physical Properties
[ Molecular Formula ]:
C15H14N4Os
[ Molecular Weight ]:
298.364
Related Compounds
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