BMS 193885

Modify Date: 2024-01-06 06:21:22

BMS 193885 structure	Common Name	BMS 193885
	CAS Number	186185-03-5	Molecular Weight	590.71000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₂N₄O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of BMS 193885

BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].

Name	dimethyl 4-[3-[3-[4-(3-methoxyphenyl)piperidin-1-yl]propylcarbamoylamino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Synonym	More Synonyms

Description	BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
Target	Ki: 3.3 nM (Neuropeptide Y1 receptor)[1] IC50: 5.9 nM (hY1)[1]
References	[1]. Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32. [2]. Poindexter GS, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82.

Molecular Formula	C₃₃H₄₂N₄O₆
Molecular Weight	590.71000
Exact Mass	590.31000
PSA	121.72000
LogP	5.21130

BMS 193885 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

MFCD16878998

BMS 193885

Use of BMS 193885

Names

BMS 193885 Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synonyms