SB 224289 hydrochloride

Modify Date: 2025-08-27 11:26:38

SB 224289 hydrochloride Structure
SB 224289 hydrochloride structure
 Common Name SB 224289 hydrochloride
CAS Number 180083-23-2 Molecular Weight 520.62
Density 1.34g/ml Boiling Point N/A
Molecular Formula C32H32N4O3 Melting Point 280℃
MSDS N/A Flash Point N/A

 Use of SB 224289 hydrochloride


SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect[1].

 Names

Name sb 224289
Synonym More Synonyms

 SB 224289 hydrochloride Biological Activity

Description SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect[1].
Related Catalog
References

[1]. Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11(5):e0154932.  

 Chemical & Physical Properties

Density 1.34g/ml
Melting Point 280℃
Molecular Formula C32H32N4O3
Molecular Weight 520.62
Exact Mass 556.224121
PSA 71.70000
LogP 6.38400

 Safety Information

Safety Phrases 22-24/25
WGK Germany 3

 Synthetic Route

Spiro[2H-furo[2,3-f]indole-3(5H),4'-piperidine], 6,7-dihydro-1'-Methyl- structure

Spiro[2H-furo[2...

CAS#:180082-56-8

[1,1'-Biphenyl]-4-carboxylic acid, 2'-Methyl-4'-(5-Methyl-1,2,4-oxadiazol-3-yl)- structure

[1,1'-Biphenyl]...

CAS#:148672-68-8

~30%

SB 224289 hydrochloride Structure

SB 224289 hydro...

CAS#:180083-23-2

Literature: SmithKline Beecham plc Patent: US5972951 A1, 1999 ;
N/A structure

N/A

CAS#:180082-58-0

~87%

SB 224289 hydrochloride Structure

SB 224289 hydro...

CAS#:180083-23-2

Literature: SmithKline Beecham plc Patent: US5972951 A1, 1999 ;
N/A structure

N/A

CAS#:165381-86-2

Spiro[2H-furo[2,3-f]indole-3(5H),4'-piperidine], 6,7-dihydro-1'-Methyl- structure

Spiro[2H-furo[2...

CAS#:180082-56-8

~30%

SB 224289 hydrochloride Structure

SB 224289 hydro...

CAS#:180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235
1-Methyl-4-(hydroxymethyl)-1,2,3,6-tetrahydropyridine structure

1-Methyl-4-(hyd...

CAS#:36166-75-3

~%

SB 224289 hydrochloride Structure

SB 224289 hydro...

CAS#:180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235
1-(6-Bromo-5-Hydroxyindolin-1-Yl)Ethanone structure

1-(6-Bromo-5-Hy...

CAS#:42443-15-2

~%

SB 224289 hydrochloride Structure

SB 224289 hydro...

CAS#:180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235
[1,1'-Biphenyl]-4-carboxylic acid, 2'-Methyl-4'-(5-Methyl-1,2,4-oxadiazol-3-yl)- structure

[1,1'-Biphenyl]...

CAS#:148672-68-8

~%

SB 224289 hydrochloride Structure

SB 224289 hydro...

CAS#:180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235

 Synonyms

(1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride (1:1)
1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] hydrochloride
Methanone, (6,7-dihydro-1'-methylspiro[2H-furo[2,3-f]indole-3(5H),4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]-, hydrochloride (1:1)
(1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methanone hydrochloride (1:1)
[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone
SB 224289 hydrochloride
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