SB 224289 hydrochloride

Modify Date: 2025-08-27 11:26:38

SB 224289 hydrochloride structure	Common Name	SB 224289 hydrochloride
	CAS Number	180083-23-2	Molecular Weight	520.62
	Density	1.34g/ml	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₂N₄O₃	Melting Point	280℃
	MSDS	N/A	Flash Point	N/A

Use of SB 224289 hydrochloride

SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect[1].

Name	sb 224289
Synonym	More Synonyms

Description	SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11(5):e0154932.

Density	1.34g/ml
Melting Point	280℃
Molecular Formula	C₃₂H₃₂N₄O₃
Molecular Weight	520.62
Exact Mass	556.224121
PSA	71.70000
LogP	6.38400
InChIKey	ATQMRMGXINTJHV-UHFFFAOYSA-N
SMILES	Cc1nc(-c2ccc(-c3ccc(C(=O)N4CCc5cc6c(cc54)C4(CCN(C)CC4)CO6)cc3)c(C)c2)no1

Safety Phrases	22-24/25
WGK Germany	3

Spiro[2H-furo[2...

CAS#:180082-56-8

[1,1'-Biphenyl]...

CAS#:148672-68-8

~30%

SB 224289 hydro...

CAS#:180083-23-2

Literature: SmithKline Beecham plc Patent: US5972951 A1, 1999 ;

N/A

CAS#:180082-58-0

~87%

SB 224289 hydro...

CAS#:180083-23-2

Literature: SmithKline Beecham plc Patent: US5972951 A1, 1999 ;

N/A

CAS#:165381-86-2

Spiro[2H-furo[2...

CAS#:180082-56-8

~30%

SB 224289 hydro...

CAS#:180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235

1-Methyl-4-(hyd...

CAS#:36166-75-3

SB 224289 hydro...

CAS#:180083-23-2

1-(6-Bromo-5-Hy...

CAS#:42443-15-2

SB 224289 hydro...

CAS#:180083-23-2

[1,1'-Biphenyl]...

CAS#:148672-68-8

SB 224289 hydro...

CAS#:180083-23-2

Precursor 3
CAS#:180082-56-8 Spiro[2H-furo[2... CAS#:36166-75-3 1-Methyl-4-(hyd... CAS#:42443-15-2 1-(6-Bromo-5-Hy...
DownStream 0

(1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride (1:1)

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] hydrochloride

Methanone, (6,7-dihydro-1'-methylspiro[2H-furo[2,3-f]indole-3(5H),4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]-, hydrochloride (1:1)

(1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methanone hydrochloride (1:1)

[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone

SB 224289 hydrochloride

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SB 224289 hydrochloride

Use of SB 224289 hydrochloride

Names

SB 224289 hydrochloride Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.