350228-36-3
350228-36-3 structure
- Name: SB 202190 hydrochloride
- Chemical Name: SB 202190 monohydrochloride hydrate
- CAS Number: 350228-36-3
- Molecular Formula: C20H15ClFN3O
- Molecular Weight: 367.80
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-04-13 23:03:51
- Modify Date: 2024-01-11 13:02:06
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SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3].
| Name | SB 202190 monohydrochloride hydrate |
|---|---|
| Synonyms |
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol hydrochloride (1:1)
SB 202190 Hydrochloride Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-, hydrochloride (1:1) 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one,hydrochloride 4-[4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol hydrochloride (1:1) |
| Description | SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3]. |
|---|---|
| Related Catalog | |
| Target |
p38α:50 nM (IC50) p38β2:100 nM (IC50) |
| In Vitro | SB 202190 (0-10 μM; 0-72 hours) hydrochloride attenuates growth of a subgroup of CRC cell lines such as RKO, CACO2 and SW480 in a dose- and time-dependent manner[1]. SB 202190 hydrochloride strongly inhibited colony formation and anchorage-independent growth (10 μM for 7-10 days) and elevated apoptotic cell death (10 μM for 72 h) in this same subset of CRC lines (RKO, CACO2 and SW480)[2]. In RKO, CACO2 and SW480 cells, SB 202190 (10 μM; 2 hours) hydrochloride abrogates phosphorylation of S6K1(T389) and S6(S235/236), but not AKT(S473), indicating that p38i selectively blocks mTORC1 signaling[2]. |
| In Vivo | SB 202190 (5 mg/kg; intraperitoneal injection; daily for 10-12 days) hydrochloride shows inhibition of tumor cell survival and tumor growth[2]. |
| References |
| Molecular Formula | C20H15ClFN3O |
|---|---|
| Molecular Weight | 367.80 |
| Exact Mass | 367.088776 |
| PSA | 61.80000 |
| LogP | 5.45240 |
| Storage condition | 2-8°C |