DC Chemicals Limited
China
Product Name: SB 224289
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)-[1,1'-BIPHENYL]-4-YL)(1'-METHYL-6,7-DIHYDROSPIRO[FURO[2,3-F]INDOLE-3,4'-PIPERIDIN]-5(2H)-YL)METHANONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

180083-23-2

180083-23-2 structure

180083-23-2 structure

Name: SB 224289 hydrochloride
Chemical Name: sb 224289
CAS Number: 180083-23-2
Molecular Formula: C₃₂H₃₂N₄O₃
Molecular Weight: 520.62
Create Date: 2018-10-13 11:06:23
Modify Date: 2024-01-04 17:41:52
SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect[1].

Name	sb 224289
Synonyms	(1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride (1:1) 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] hydrochloride Methanone, (6,7-dihydro-1'-methylspiro[2H-furo[2,3-f]indole-3(5H),4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]-, hydrochloride (1:1) (1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methanone hydrochloride (1:1) [4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone SB 224289 hydrochloride

Description	SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11(5):e0154932.

Density	1.34g/ml
Melting Point	280℃
Molecular Formula	C₃₂H₃₂N₄O₃
Molecular Weight	520.62
Exact Mass	556.224121
PSA	71.70000
LogP	6.38400

Safety Phrases	22-24/25
WGK Germany	3

180082-56-8 structure

180082-56-8

148672-68-8 structure

148672-68-8

~30%

180083-23-2 structure

180083-23-2

Literature: SmithKline Beecham plc Patent: US5972951 A1, 1999 ;

180082-58-0 structure

180082-58-0

~87%

180083-23-2 structure

180083-23-2

Literature: SmithKline Beecham plc Patent: US5972951 A1, 1999 ;

165381-86-2 structure

165381-86-2

180082-56-8 structure

180082-56-8

~30%

180083-23-2 structure

180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235

36166-75-3 structure

36166-75-3

~%

180083-23-2 structure

180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235

42443-15-2 structure

42443-15-2

~%

180083-23-2 structure

180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235

148672-68-8 structure

148672-68-8

~%

180083-23-2 structure

180083-23-2

Literature: Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235

Precursor 3
180082-56-8 36166-75-3 42443-15-2
DownStream 0