2-Methylquinazolin-4-ol structure
|
Common Name | 2-Methylquinazolin-4-ol | ||
---|---|---|---|---|
CAS Number | 1769-24-0 | Molecular Weight | 160.17300 | |
Density | 1.26 g/cm3 | Boiling Point | 305.4ºC at 760 mmHg | |
Molecular Formula | C9H8N2O | Melting Point | 231-233ºC(lit.) | |
MSDS | N/A | Flash Point | 138.5ºC |
Use of 2-Methylquinazolin-4-ol2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2]. |
Name | 2-Methylquinazolin-4-ol |
---|---|
Synonym | More Synonyms |
Description | 2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2]. |
---|---|
Related Catalog | |
In Vitro | 2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1]. |
In Vivo | 2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2]. Animal Model: Mice[2] Dosage: 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg Administration: Oral gavage, for two days Result: Showed an inhibitory effect upon ATCase. |
References |
Density | 1.26 g/cm3 |
---|---|
Boiling Point | 305.4ºC at 760 mmHg |
Melting Point | 231-233ºC(lit.) |
Molecular Formula | C9H8N2O |
Molecular Weight | 160.17300 |
Flash Point | 138.5ºC |
Exact Mass | 160.06400 |
PSA | 45.75000 |
LogP | 1.23150 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Hazard Codes | Xi: Irritant; |
---|---|
Risk Phrases | R36/37/38 |
Safety Phrases | S26;S37/S39 |
WGK Germany | 3 |
RTECS | VA3677000 |
HS Code | 2933990090 |
Precursor 9 | |
---|---|
DownStream 10 | |
HS Code | 2933990090 |
---|---|
Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
EINECS 217-189-2 |
MFCD00006887 |
2-methyl-4(3h)-quinazolinone |