ACY-1083

Modify Date: 2025-09-01 18:11:13

ACY-1083 Structure
ACY-1083 structure
 Common Name ACY-1083
CAS Number 1708113-43-2 Molecular Weight 348.35
Density N/A Boiling Point N/A
Molecular Formula C17H18F2N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACY-1083


ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].

 Names

Name ACY-1083

 ACY-1083 Biological Activity

Description ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].
Related Catalog
Target

HDAC6:3 nM (IC50)

References

[1]. Krukowski K, et al. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain. 2017 Jun;158(6):1126-1137.

 Chemical & Physical Properties

Molecular Formula C17H18F2N4O2
Molecular Weight 348.35
InChIKey MRWCVKLVSWYIFO-UHFFFAOYSA-N
SMILES O=C(NO)c1cnc(NC2(c3ccccc3)CCC(F)(F)CC2)nc1
Storage condition 2-8℃
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Chemsrc provides ACY-1083(CAS#:1708113-43-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ACY-1083 are included as well.>> amp version: ACY-1083

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