ACY-1083

Modify Date: 2024-01-09 18:11:02

ACY-1083 structure	Common Name	ACY-1083
	CAS Number	1708113-43-2	Molecular Weight	348.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₈F₂N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ACY-1083

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].

Name	ACY-1083

Description	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:3 nM (IC50)
References	[1]. Krukowski K, et al. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain. 2017 Jun;158(6):1126-1137.

Molecular Formula	C₁₇H₁₈F₂N₄O₂
Molecular Weight	348.35
Storage condition	2-8℃

ACY-1083

Use of ACY-1083

Names

ACY-1083 Biological Activity

Chemical & Physical Properties