1708113-43-2

1708113-43-2 structure

Name: ACY-1083
Chemical Name: ACY-1083
CAS Number: 1708113-43-2
Molecular Formula: C₁₇H₁₈F₂N₄O₂
Molecular Weight: 348.35
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2019-06-01 20:49:50
Modify Date: 2024-01-09 18:11:02
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].

Name	ACY-1083

Description	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:3 nM (IC50)
References	[1]. Krukowski K, et al. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain. 2017 Jun;158(6):1126-1137.