ACY-957
Modify Date: 2025-08-29 15:59:34
ACY-957 structure
|
Common Name | ACY-957 | ||
|---|---|---|---|---|
| CAS Number | 1609389-52-7 | Molecular Weight | 429.537 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 602.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C24H23N5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 318.3±31.5 °C | |
Use of ACY-957ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. |
| Name | ACY-957 |
|---|---|
| Synonym | More Synonyms |
| Description | ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. |
|---|---|
| Related Catalog | |
| Target |
HDAC1:7 nM (IC50) HDAC2:18 nM (IC50) HDAC3:1300 nM (IC50) |
| In Vitro | ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 602.7±55.0 °C at 760 mmHg |
| Molecular Formula | C24H23N5OS |
| Molecular Weight | 429.537 |
| Flash Point | 318.3±31.5 °C |
| Exact Mass | 429.162323 |
| LogP | 2.73 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.726 |
| InChIKey | VURDNNVAYZDGDK-UHFFFAOYSA-N |
| SMILES | Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc2nc(N3CCNCC3)ccc2c1 |
| Storage condition | 2-8℃ |
| 6-Quinolinecarboxamide, N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)- |
| N-[2-Amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide |