1316215-12-9

1316215-12-9 structure

Name: Citarinostat
Chemical Name: Citarinostat
CAS Number: 1316215-12-9
Molecular Formula: C₂₄H₂₆ClN₅O₃
Molecular Weight: 467.948
Catalog: Research Areas Cancer
Create Date: 2018-12-14 21:01:53
Modify Date: 2024-01-14 11:59:22
Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and 2015054197A1.

Name	Citarinostat
Synonyms	2-[(2-Chlorophenyl)(phenyl)amino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide Citarinostat 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxohepl)pyrimidine-5-carboxamide 5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]- 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide ACY-241 UNII:441P620G3P ACY-241 Avi Tini

Description	Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and 2015054197A1.
Related Catalog	Research Areas >> Cancer
Target	HDAC6:2.6 nM (IC50) HDAC1:35 nM (IC50) HDAC2:45 nM (IC50) HDAC3:46 nM (IC50) HDAC8:137 nM (IC50) HDAC7:7300 nM (IC50)
References	[1]. Huang P, et al. Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models. Oncotarget. 2017 Jan 10;8(2):2694-2707. [2]. From PCT Int. Appl. (2015), WO 2015054197 A1 20150416.