Leelamine hydrochloride

Modify Date: 2024-01-12 15:33:34

Leelamine hydrochloride Structure
Leelamine hydrochloride structure
Common Name Leelamine hydrochloride
CAS Number 16496-99-4 Molecular Weight 321.928
Density N/A Boiling Point N/A
Molecular Formula C20H32ClN Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Leelamine hydrochloride


Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

 Names

Name [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine,hydrochloride
Synonym More Synonyms

 Leelamine hydrochloride Biological Activity

Description Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].
Related Catalog
Target

CB1

References

[1]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

[2]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012

[3]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

 Chemical & Physical Properties

Molecular Formula C20H32ClN
Molecular Weight 321.928
Exact Mass 321.222321
PSA 26.02000
LogP 6.28130

 Safety Information

Hazard Codes Xi

 Synonyms

Abieta-8(14),9(11),12-trien-18-amine hydrochloride (1:1)
1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-, hydrochloride (1:1)
13-Isopropyl-podocarpa-8,11,13-trien-15-amine Hydrochloride
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl-1-phenanthrenemethanamine) Hydrochloride
Dehydroabiethylamine Hydrochloride
Leelamine Hydrochloride
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