Norepinephrine hydrochloride
Modify Date: 2024-01-06 23:35:25
Norepinephrine hydrochloride structure
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Common Name | Norepinephrine hydrochloride | ||
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| CAS Number | 329-56-6 | Molecular Weight | 205.639 | |
| Density | 1.397g/cm3 | Boiling Point | 442.6ºC at 760mmHg | |
| Molecular Formula | C8H12ClNO3 | Melting Point | -150ºC (dec.) | |
| MSDS | N/A | Flash Point | 221.5ºC | |
Use of Norepinephrine hydrochlorideNorepinephrine hydrochloride is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. |
| Name | l-noradrenaline hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Norepinephrine hydrochloride is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. |
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| Related Catalog | |
| Target |
EC50: 5.37 μM (β1-selective adrenergic receptor)[1] |
| In Vitro | Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2]. |
| Cell Assay | Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2]. |
| References |
| Density | 1.397g/cm3 |
|---|---|
| Boiling Point | 442.6ºC at 760mmHg |
| Melting Point | -150ºC (dec.) |
| Molecular Formula | C8H12ClNO3 |
| Molecular Weight | 205.639 |
| Flash Point | 221.5ºC |
| Exact Mass | 205.050568 |
| PSA | 86.71000 |
| LogP | 1.59220 |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Norepinephrine ... CAS#:329-56-6 |
| Literature: Hagen, Volker; Dekowski, Brigitte; Kotzur, Nico; Lechler, Ralf; Wiesner, Burkhard; Briand, Benoit; Beyermann, Michael Chemistry - A European Journal, 2008 , vol. 14, # 5 p. 1621 - 1627 |
![N-{{7-[bis(carboxymethyl)amino]coumarin-4-yl}methyloxycarbonyl}-L-norepinephrine structure](https://www.chemsrc.com/caspic/053/1031721-23-9.png)
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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