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Leelamine hydrochloride

Names

[ CAS No. ]:
16496-99-4

[ Name ]:
Leelamine hydrochloride

[Synonym ]:
Abieta-8(14),9(11),12-trien-18-amine hydrochloride (1:1)
1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-, hydrochloride (1:1)
13-Isopropyl-podocarpa-8,11,13-trien-15-amine Hydrochloride
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl-1-phenanthrenemethanamine) Hydrochloride
Dehydroabiethylamine Hydrochloride
Leelamine Hydrochloride

Biological Activity

[Description]:

Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Signaling Pathways >> Others >> Androgen Receptor

[Target]

CB1


[References]

[1]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

[2]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012

[3]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H32ClN

[ Molecular Weight ]:
321.928

[ Exact Mass ]:
321.222321

[ PSA ]:
26.02000

[ LogP ]:
6.28130

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds