16496-99-4

16496-99-4 structure

Name: Leelamine hydrochloride
Chemical Name: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine,hydrochloride
CAS Number: 16496-99-4
Molecular Formula: C₂₀H₃₂ClN
Molecular Weight: 321.928
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2016-04-26 00:33:45
Modify Date: 2024-01-12 15:33:34
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

Name	[(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine,hydrochloride
Synonyms	Abieta-8(14),9(11),12-trien-18-amine hydrochloride (1:1) 1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-, hydrochloride (1:1) 13-Isopropyl-podocarpa-8,11,13-trien-15-amine Hydrochloride (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl-1-phenanthrenemethanamine) Hydrochloride Dehydroabiethylamine Hydrochloride Leelamine Hydrochloride

Description	Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Signaling Pathways >> Others >> Androgen Receptor
Target	CB1
References	[1]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703. [2]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012 [3]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

Hazard Codes	Xi