EGFR/HER2-IN-9

Modify Date: 2025-09-21 09:46:26

EGFR/HER2-IN-9 structure	Common Name	EGFR/HER2-IN-9
	CAS Number	1637253-79-2	Molecular Weight	513.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₅ClFN₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EGFR/HER2-IN-9

EGFR/HER2-IN-9 (Compound 1) is an EGFR and HER2 inhibitor with IC50s of 3.2, 8.3 and 14 nM against EGFR, EGFR T790M and HER2, respectively[1].

Name	EGFR/HER2-IN-9

Description	EGFR/HER2-IN-9 (Compound 1) is an EGFR and HER2 inhibitor with IC50s of 3.2, 8.3 and 14 nM against EGFR, EGFR T790M and HER2, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:3.2 nM (IC50) EGFRT790M:8.3 nM (IC50) HER2:14 nM (IC50)
References	[1]. Yingjun Zhang, et al. Amino quinazoline derivatives as well as salts and application method thereof. Patent CN104119350A.

Molecular Formula	C₂₅H₂₅ClFN₅O₄
Molecular Weight	513.95
InChIKey	REGOTSLWVKSZRG-GYQWKJCYSA-N
SMILES	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN1CC2OCCOC2C1

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