EGFR/HER2/TS-IN-2

Modify Date: 2025-08-27 07:07:31

EGFR/HER2/TS-IN-2 Structure
EGFR/HER2/TS-IN-2 structure
 Common Name EGFR/HER2/TS-IN-2
CAS Number 2444364-04-7 Molecular Weight 511.62
Density N/A Boiling Point N/A
Molecular Formula C26H21N7OS2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EGFR/HER2/TS-IN-2


EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].

 Names

Name EGFR/HER2/TS-IN-2

 EGFR/HER2/TS-IN-2 Biological Activity

Description EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM[1].
Related Catalog
Target

EGFR:0.173 ± 0. μM (IC50)

HER2:0.125 ± 0. μM (IC50)

In Vitro EGFR/HER2/TS-IN-2 (compound 17) shows the GI (growth inhibition)=53.20 and 49.35% towards ovarian cancer IGROV1 and renal cancer UO-31, respectively[1].
References

[1]. Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976.

 Chemical & Physical Properties

Molecular Formula C26H21N7OS2
Molecular Weight 511.62
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