Lanicemine dihydrochloride
Modify Date: 2024-01-03 19:41:28
Lanicemine dihydrochloride structure
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Common Name | Lanicemine dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 153322-06-6 | Molecular Weight | 271.185 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H16Cl2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Lanicemine dihydrochlorideLanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1]. |
| Name | 59E712CNQR |
|---|---|
| Synonym | More Synonyms |
| Description | Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1]. |
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| Related Catalog | |
| Target |
NMDA receptor[1] |
| In Vivo | Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |
| References |
| Molecular Formula | C13H16Cl2N2 |
|---|---|
| Molecular Weight | 271.185 |
| Exact Mass | 270.069061 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| (1S)-1-Phenyl-2-(2-pyridinyl)ethanamine dihydrochloride |
| LANICEMINE DIHYDROCHLORIDE |
| 59E712CNQR |
| 2-Pyridineethanamine, α-phenyl-, (αS)-, hydrochloride (1:2) |
| MFCD00936874 |