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Lanicemine dihydrochloride

Names

[ CAS No. ]:
153322-06-6

[ Name ]:
Lanicemine dihydrochloride

[Synonym ]:
(1S)-1-Phenyl-2-(2-pyridinyl)ethanamine dihydrochloride
LANICEMINE DIHYDROCHLORIDE
59E712CNQR
2-Pyridineethanamine, α-phenyl-, (αS)-, hydrochloride (1:2)
MFCD00936874

Biological Activity

[Description]:

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

NMDA receptor[1]


[In Vivo]

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.

[References]

[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H16Cl2N2

[ Molecular Weight ]:
271.185

[ Exact Mass ]:
270.069061

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds